Fosamax & Osteonecrosis
Fosamax (Alendronate) is used to increase bone density, reduce bone fractures and prevent and/or treat osteoporosis. The drug, which is manufactured by Merck & Company, has recently been linked to cases of Osteonecrosis of the jaw. This rare condition involves the loss, breakdown, or “death” of the jaw bone, commonly leading to serious infection and fractures that require long-term care to correct. The condition is irreversible.
Fosamax is part of a class of drugs called Bisphosphonates. Bisphosphonates are prescribed to prevent osteoporosis by attaching permanently to the surface of the bone, thus slowing tissue deterioration. The three types of bisphosphonates: alendrote (Fosamax), etidronate (Didrocal) and risedronate (Actonel), all help to increase bone density and prevent fractures of the spine. However, all three have recently been linked to Osteonecrosis of the jaw, a condition in which bone tissue in the jaw does not heal properly.
Osteonecrosis of the jaw (pronounced OSS-tee-oh-ne-KRO-sis) can be a very serious condition. Symptoms include: pain, swelling, or infection of the gums, loosening of teeth, poor healing of the gums, and numbness or the feeling of heaviness in the jaw. Experts recommend early treatment of individuals using bisphosphonates such as Fosamax, saying this is the only way to preserve the jaw bone.
There are certain factors that are known to increase the likelihood of Osteonecrosis of the Jaw:
- Radiation therapy to the head or neck
- Chemotherapy
- Steroid therapy (for example, cortisone)
- Underlying cancer
- Anemia (low blood count) and other bloodrelated disorders
- Infection
- A history of poor dental health
- Gum disease or dental surgery (such as pulled teeth)
- Alcohol abuse or cigarette smoking
- Poor nutrition
- Poor blood circulation or clotting problems
There have been many reported side effects from Fosamax including: Osteonecrosis of the jaw (ONJ), ulcers in the esophagus, acid regurgitation, bone and joint pain, constipation, nausea and abdominal pain. Fosamax is not recommended for women on hormone replacement therapy, or for women with kidney problems.
If you or a loved one have experienced side effects from Fosamax including Osteonecrosis of the Jaw, please call us at (800) 966-4999 or fill out our online contact form for a free case evaluation.
